Endocrine Abstracts

Background: This project endeavoured to improve the quality of endocrinology teaching to clinical medical students through the use of a new multi-stage process.Methods: We created a co-ordinated block containing 4-h teaching sessions (4×1 h) in which eight students in their first clinical year presented answers to questions based on clinical endocrinology cases they had seen and selected. The process started with identification of cases in the out-p...

Background: Testicular germ cell tumours are the most frequent cancer of young men. While pathogenesis and reasons of an increasing incidence all over the world remain unknown, epidemiological and clinical data have suggested that fetal exposure to environmental endocrine disruptors (EEDs), especially with estrogenic effects, could participate to testicular germ cell carcinogenesis. However, EEDs (like bisphenol A) are often weak ligands for classical nuclear estrogen receptor...

Cushing’s syndrome (CS) is a hormonal disorder characterized by chronic high levels of circulating cortisol. Patients treated for CS develop chronic adrenal insufficiency (AI) and hypothalamus-pituitary-adrenal (HPA) axis dysfunction. Long-term treatment with glucocorticoids (GC) is mandatory to overcome AI. Fibroblast growth factor (FGF) -21, a key regulator of metabolism, has a bidirectional relationship with GC that bypasses the negative feedback of the HPA axis. In th...

Introduction: Environmental pollutants especially those endowed with endocrine disrupting activities have been shown to contribute to metabolic related diseases suggesting that hormonal deficit conditions as observed in post-menopausal women may constitute aggravating conditions. To explore this hypothesis, we used the model developed in the laboratory which consists in a chronically exposure of mice to low-dosed chemicals in mixture incorporated in a high-fat-high-sucrose die...

Background: The finding of severe hyperandrogenemia, rapidly progressive clinical hyperandrogenism, defeminization and/or virilization in women of any age should raise the suspicion of an ovarian or adrenal malignancy. Similarly, moderate to severe hyperandrogenemia after menopause, and its clinic consequences, force clinicians to rule out a tumoral source.Matherial and methods: Observational cross-sectional study conducted in patients derived to our cli...

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Seventy percent of women bearing PCOS are obese; adiponectin and TNFα, as obesity markers, have a dual role in the sensitivity and action of insulin. Adiponectin (insulin sensitising) decreases, whereas, TNFα, IL6 (negative regulators of insulin pathway) increases in obese-women. Moreover, TNFα decreases the transcript and protein levels of adiponectin. These changes could affect the normal energetic status in endometrium, tissue that exhibits abnormal insulin s...

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these endocrine disruptors have only a weak affinity for the classical ERs and other mechanisms have been suggested. Bisphenol A, a chemical poluttant, used as monomer to manufacture polycarbonate plastic, released from lining canned food or beverages or from dental sealants, was able to promote human testicular seminoma cell (JKT-1) proliferation <...

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Goals: To analyze the mortality rate (M) in patients with DM who undergo some medical decompensation during an admission to Orthopedic Surgery and Traumatology (OST).Material and methods: Descriptive analysis of patients admitted to OST who suffered some type of medical decomp...